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saco-indonesia.com, Real Madrid gagal dalam memanfaatkan kesempatan untuk dapat menembus dua besar La Liga setelah semalam hanya

saco-indonesia.com, Real Madrid gagal dalam memanfaatkan kesempatan untuk dapat menembus dua besar La Liga setelah semalam hanya bermain imbang 1-1 dalam melawan Athletic Bilbao di San Mames. Dalam laga yang berlangsung dalam tensi tinggi tersebut, juga sempat muncul insiden kontroversial saat Cristiano Ronaldo dikartu merah oleh Wasit Miguel Ayza.

Hukuman tersebut telah dijatuhkan setelah pemain asal Portugal ini karena dianggap mendorong wajah defender Bilbao, Carlos Gurpegui. Insiden ini juga sempat menimbulkan keributan antara pemain kedua tim di atas lapangan.

Pelatih Madrid, Carlo Ancelotti sebelumnya juga telah menyatakan bahwa hukuman kartu merah yang telah diterima Ronaldo terlalu kelewatan. Namun pendapat berbeda telah diungkapkan Entrenador Bilbao, Ernesto Valverde.

"Saya juga tidak melihat kejadian itu secara langsung. Namun saya pikir apa yang ia lakukan sudah lebih dari cukup untuk diganjar kartu merah," kata pria 49 tahun ini.

Kartu merah yang diterima sang winger produktif telah membuat daya serang El Real berkurang sehingga gagal memburu gol kemenangan. Tim tamu unggul terlebih dahulu di menit ke 65 melalui Jese Rodriguez, sebelum akhirnya sepuluh menit kemudian pemain pengganti Ibai Gomez menyamakan kedudukan 1-1.


Editor : Dian Sukmawati

Selama ribuan tahun, jahe sudah dikelompokkan sebagai penyedap masakan dan minuman, serta pengobatan.

Saco- Indonesia.com - Selama ribuan tahun, jahe sudah dikelompokkan sebagai penyedap masakan dan minuman, serta pengobatan. Tanaman rimpang ini disukai karena efeknya yang menghangatkan tubuh. Salah satu khasiat lain dari jahe adalah membantu mengurangi gejala asma.

Para peneliti dari departemen anestesiologi Columbia University mengatakan, jika dikombinasikan dengan obat-obatan asma, jahe akan meningkatkan  efek rileksasi otot polos di sekitar saluran napas. Otot-otot ini menyempit saat serangan asma terjadi sehingga menyulitkan untuk bernapas.

Para peneliti menemukan ada tiga komponen spesifik dari jahe yang memiliki efek rileksasi sehingga baik jika dikombinasikan dengan obat asma. Ketua studi Elizabeth Townsend mengatakan, komponen jahe yang telah dimurnikan dapat bekerja secara sinergi dengan pengobatan asma dalam rileksasi otot saluran napas.

"Prevalensi asma meningkat beberapa tahun terakhir, namun dengan pengetahuan yang lebih baik tentang penyebabnya dan bagaimana penyakit ini berkembang, maka pengobatan baru yang lebih efektif dapat diciptakan," ujar Townsend.

Asma dikendalikan oleh otot yang mengetat di saluran udara yang disebut bronkokonstriksi. Maka selama ini asma diobati dengan betagonists yang berfungsi mengendurkan otot.

Untuk mengukur efek dari jahe, para peneliti mengambil sampel jaringan otot saluran napas dan memberikan paparan sebuah senyawa neurotransmiter yang disebut asetilkolin untuk membuat otot berkontraksi. Kemudian mereka memberikan tiga perlakukan berbeda pada otot polos yang berkontraksi tersebut.

Perlakukan pertama yaitu dengan memberikan isoproterenol, salah satu tipe bronkodilator, yang dicampur dengan komponen jahe 6-gingerol. Kedua, pengobatan ditambah komponen jahe 8-gingerol, dan yang tiga pengobatan ditambah komponen jahe 6-shogaol. Sedangkan ada juga kontrol yaitu dengan hanya memberikan pengobatan saja.

Hasilnya, ketiga perlakuan memberikan hasil yang lebih baik dibandingkan pengobatan saja. Khususnya, 6-shogaol merupakan komponen yang paling efektif dalam mengendurkan otot yang memperbaiki pengobatan asma.

Ketiga komponen bekerja dengan mempengaruhi enzim yang disebut dengan phosphodiesterase 4D (PDE4D). Penelitian sebelumnya menunjukkan enzim tersebut ditemukan di paru-paru, menghambat mekanisme rileksasi di saluran napas dan mengurangi inflamasi jaringan.

Para peneliti berharap studi ini dapat memberikan penjelasan yang lebih lanjut hingga ke tingkat seluler mengenai efektivitas komponen jahe untuk pengobatan saluran napas.


Sumber :Medical Daily/Kompas.com
Editor :Liwon Maulana(galipat)

At the National Institutes of Health, Dr. Suzman’s signature accomplishment was the central role he played in creating a global network of surveys on aging.

Even as a high school student, Dave Goldberg was urging female classmates to speak up. As a young dot-com executive, he had one girlfriend after another, but fell hard for a driven friend named Sheryl Sandberg, pining after her for years. After they wed, Mr. Goldberg pushed her to negotiate hard for high compensation and arranged his schedule so that he could be home with their children when she was traveling for work.

Mr. Goldberg, who died unexpectedly on Friday, was a genial, 47-year-old Silicon Valley entrepreneur who built his latest company, SurveyMonkey, from a modest enterprise to one recently valued by investors at $2 billion. But he was also perhaps the signature male feminist of his era: the first major chief executive in memory to spur his wife to become as successful in business as he was, and an essential figure in “Lean In,” Ms. Sandberg’s blockbuster guide to female achievement.

Over the weekend, even strangers were shocked at his death, both because of his relatively young age and because they knew of him as the living, breathing, car-pooling center of a new philosophy of two-career marriage.

“They were very much the role models for what this next generation wants to grapple with,” said Debora L. Spar, the president of Barnard College. In a 2011 commencement speech there, Ms. Sandberg told the graduates that whom they married would be their most important career decision.

In the play “The Heidi Chronicles,” revived on Broadway this spring, a male character who is the founder of a media company says that “I don’t want to come home to an A-plus,” explaining that his ambitions require him to marry an unthreatening helpmeet. Mr. Goldberg grew up to hold the opposite view, starting with his upbringing in progressive Minneapolis circles where “there was woman power in every aspect of our lives,” Jeffrey Dachis, a childhood friend, said in an interview.

The Goldberg parents read “The Feminine Mystique” together — in fact, Mr. Goldberg’s father introduced it to his wife, according to Ms. Sandberg’s book. In 1976, Paula Goldberg helped found a nonprofit to aid children with disabilities. Her husband, Mel, a law professor who taught at night, made the family breakfast at home.

Later, when Dave Goldberg was in high school and his prom date, Jill Chessen, stayed silent in a politics class, he chastised her afterward. He said, “You need to speak up,” Ms. Chessen recalled in an interview. “They need to hear your voice.”

Years later, when Karin Gilford, an early employee at Launch Media, Mr. Goldberg’s digital music company, became a mother, he knew exactly what to do. He kept giving her challenging assignments, she recalled, but also let her work from home one day a week. After Yahoo acquired Launch, Mr. Goldberg became known for distributing roses to all the women in the office on Valentine’s Day.

Ms. Sandberg, who often describes herself as bossy-in-a-good-way, enchanted him when they became friendly in the mid-1990s. He “was smitten with her,” Ms. Chessen remembered. Ms. Sandberg was dating someone else, but Mr. Goldberg still hung around, even helping her and her then-boyfriend move, recalled Bob Roback, a friend and co-founder of Launch. When they finally married in 2004, friends remember thinking how similar the two were, and that the qualities that might have made Ms. Sandberg intimidating to some men drew Mr. Goldberg to her even more.

Over the next decade, Mr. Goldberg and Ms. Sandberg pioneered new ways of capturing information online, had a son and then a daughter, became immensely wealthy, and hashed out their who-does-what-in-this-marriage issues. Mr. Goldberg’s commute from the Bay Area to Los Angeles became a strain, so he relocated, later joking that he “lost the coin flip” of where they would live. He paid the bills, she planned the birthday parties, and both often left their offices at 5:30 so they could eat dinner with their children before resuming work afterward.

Friends in Silicon Valley say they were careful to conduct their careers separately, politely refusing when outsiders would ask one about the other’s work: Ms. Sandberg’s role building Facebook into an information and advertising powerhouse, and Mr. Goldberg at SurveyMonkey, which made polling faster and cheaper. But privately, their work was intertwined. He often began statements to his team with the phrase “Well, Sheryl said” sharing her business advice. He counseled her, too, starting with her salary negotiations with Mark Zuckerberg.

“I wanted Mark to really feel he stretched to get Sheryl, because she was worth it,” Mr. Goldberg explained in a 2013 “60 Minutes” interview, his Minnesota accent and his smile intact as he offered a rare peek of the intersection of marriage and money at the top of corporate life.

 

 

While his wife grew increasingly outspoken about women’s advancement, Mr. Goldberg quietly advised the men in the office on family and partnership matters, an associate said. Six out of 16 members of SurveyMonkey’s management team are female, an almost unheard-of ratio among Silicon Valley “unicorns,” or companies valued at over $1 billion.

When Mellody Hobson, a friend and finance executive, wrote a chapter of “Lean In” about women of color for the college edition of the book, Mr. Goldberg gave her feedback on the draft, a clue to his deep involvement. He joked with Ms. Hobson that she was too long-winded, like Ms. Sandberg, but aside from that, he said he loved the chapter, she said in an interview.

By then, Mr. Goldberg was a figure of fascination who inspired a “where can I get one of those?” reaction among many of the women who had read the best seller “Lean In.” Some lamented that Ms. Sandberg’s advice hinged too much on marrying a Dave Goldberg, who was humble enough to plan around his wife, attentive enough to worry about which shoes his young daughter would wear, and rich enough to help pay for the help that made the family’s balancing act manageable.

Now that he is gone, and Ms. Sandberg goes from being half of a celebrated partnership to perhaps the business world’s most prominent single mother, the pages of “Lean In” carry a new sting of loss.

“We are never at 50-50 at any given moment — perfect equality is hard to define or sustain — but we allow the pendulum to swing back and forth between us,” she wrote in 2013, adding that they were looking forward to raising teenagers together.

“Fortunately, I have Dave to figure it out with me,” she wrote.

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